The Efficacy of Telemental Health Interventions for Mood Disorders Pre-COVID-19: A Narrative Review

The onset of the COVID-19 pandemic saw a significant surge in the utilization of telemental health (TMH) services. This narrative review aimed to investigate the efficacy of TMH for serious mood disorders prior to the COVID-19 pandemic. A search across databases was conducted for randomized controlled trials focusing on TMH interventions for mood disorders, encompassing major depressive disorder (MDD) and bipolar disorder (BD). Study and patient characteristics, interventions, and outcomes were extracted. From a pool of 2611 papers initially identified, 17 met the inclusion criteria: 14 focused on MDD, while 4 addressed BD. Among these, 6 papers directly compared TMH interventions to in-person of same treatment, revealing improved access to care and higher rates of appointment follow-up with TMH. Additionally, 6 papers comparing TMH to treatment as usual demonstrated improvements in mood outcomes. Conversely, 3 papers comparing different TMH interventions found no discernible differences in outcomes. Notably, 3 studies evaluated TMH as an adjunct to usual care, all reporting enhancements in depression outcomes. Overall, preliminary evidence suggests that prior to COVID-19, TMH interventions for serious mood disorders facilitated improved access to care and follow-up, with comparable clinical outcomes to traditional in-person interventions. The discussion addresses limitations and provides recommendations for future research in this domain. Supplementary Information The online version contains supplementary material available at 10.1007/s11414-024-09884-5.


Introduction
The US National Institute of Mental Health (NIMH) defines telemental health (TMH) as "the use of telecommunications or videoconferencing technology to provide mental health services." 1 TMH can provide a range of services including psychiatric evaluations, therapy, patient education, and medication management through a live and interactive technological interface.Given the limited workforce in psychiatry, even prior to COVID-19, there has been a higher demand, compared to the available supply of mental health providers and resources. 2TMH offers efficient use of scarce resources.Since its inception, TMH has improved access to mental health care, allowed healthcare providers to treat more patients in distant locations, and has contributed to patient satisfaction. 3he use of videoconferencing in the field of psychiatry began in 1959 when the Nebraska Psychiatric Institute utilized videoconferencing to provide group therapy, long-term therapy, consultationliaison psychiatry, and medical student training at the Nebraska State Hospital in Norfolk. 4 TMH grew in popularity throughout the 1970s and 1980s and eventually spread across the world in the 1990s. 4As it became more commonly used, researchers began to evaluate TMH's ability to facilitate access to care, overcome geographical obstacles, and how it compared to in-person care.By the 2000s, it became clear that TMH can be effective, but is distinctly different from in-person care. 4In February 2018, the American Psychiatric Association (APA) updated its public recommendations, stating "Telemedicine in psychiatry, using videoconferencing, is a validated and effective practice of medicine that increases access to care." 3 During the COVID-19 public health emergency (PHE), there was a dramatic increase in the use of TMH services. 5In June 2020, near the beginning of the COVID-19 pandemic, the APA conducted a survey that included a question regarding the use of TMH prior to the COVID PHE.Of the 600 psychiatrist respondents, 64% reported not seeing any of their patient caseload via TMH health prior to the PHE. 5 In contrast, when the survey was repeated in January 2021, 81% of respondents reported that they were seeing the vast majority of their patients (between 75 and 100%) via TMH, with 39% reporting transitioning back to seeing at least some patients in-person. 5n addition to psychiatrists, diverse mental health professionals including psychologists, counselors, social workers, and psychiatric nurses have increased their use of TMH service delivery. 2onsidering the dramatic shift towards utilizing TMH, it was of interest to investigate the body of research on the efficacy of TMH interventions for the treatment of serious mood disorders that existed prior to the COVID-19 pandemic.7][8] Care for individuals with serious mood disorders often includes evaluation of risk to self and can involve multiple treatment modalities such as medication and behavioral therapies.A recent meta-analysis found a limited number of randomized controlled trials in TMH research focused on mood disorder treatments. 9he objective of this narrative review was to assess the efficacy of TMH for the treatment of individuals with serious mood disorders, including major depressive disorder (MDD) and bipolar disorder (BD), a subset of serious mental illness, prior to the onset of the COVID-19 pandemic.).The complete search strategy for each database is included in Appendix 1.The search included combinations of the following keywords: telemedicine, telehealth, telepsychiatry, remote delivery, virtual delivery, serious mental illness, severe mental illness, major depression, and bipolar and related disorders.Additionally, a review of the bibliographies of the final pool of articles was conducted to identify any additional relevant articles.

Methods
Serious mood disorders were defined as bipolar disorder (BD) or major depressive disorder (MDD), with diagnosis determined based on patient self-report, clinical evaluation, standardized diagnostic interview, or medical record review.Papers that solely classified cases based on symptom reports or depression severity scale usage (e.g., PHQ-9) were excluded.Only randomized controlled trials (RCT) conducted pre-COVID with at least one patient-level outcome were included.Papers including other psychiatric or medical conditions were eligible if subgroup analyses of individuals with a serious mood disorder diagnosis were reported.Interventions where the delivery was primarily or entirely remote by a clinician (e.g., doctor, nurse, social worker, counselor) using interactive real-time technology, or via telephone, were included.
Exclusion criteria covered four categories: diagnosis, type of TMH intervention, patient outcomes, and study design.Interventions primarily focusing on substance use/abuse or other conditions not classified as serious mood disorders, such as post-traumatic stress disorder or premenstrual dysmorphic disorder, were excluded.Papers evaluating a mood disorder but lacking separate analyses of BD or MDD samples were also excluded, as were primarily automated therapies or apps.
All abstracts underwent relevance screening by three authors (AE, JP, JL), excluding systematic reviews, retrospective studies, and case reports.To ensure that the inclusion and exclusion criteria were being applied in the same way, three of the authors performed a dry run of abstract review.The first 10 abstracts from PubMed were compiled into an Excel spreadsheet, and the authors independently determined whether the papers met inclusion/exclusion criteria.The three authors then compared decisions and reached consensus on any discrepancies before applying uniform criteria to the remaining papers.
Papers were categorized into four different comparison types: (1) direct comparison of TMH vs same treatment delivered in-person, (2) TMH + In-person vs In-person alone (TMH as add on to usual care), (3) TMH intervention versus in-person standard care control, and (4) TMH vs another telehealth control (such as telephone-delivered calls recalling neutral events).

Analytical Strategies
A data extraction checklist was developed to code study characteristics including author, year, study design, sample description, control group, intervention, outcome measurement, and results.To rate the methodological quality of papers, a modified version of the Methodological Quality Rating Scale (MQRS) was employed. 10This rating scale assesses the methodological quality of papers across 12 different dimensions (for example, study design and follow-up length).Cumulative MQRS scores for each study range from one (poor quality) to 16 (high quality).A score of 14 or higher is considered well-designed, 7-13 is moderate, and a score of 1-6 is considered low quality.

Study Selection
The literature search returned a total of 2611 papers.After removal of 1172 duplicates, a total of 1439 publications were screened.Following abstract and title screening as well as scanning the references of selected papers, 28 papers underwent full-text screening and data extraction, and 17 met inclusion criteria and were included in the final narrative review (Fig. 1).Of the 17 included papers, there were only 16 original studies as two papers were based upon the same study. 11,12

Study Design
The study design of all the included studies was RCTs, ranging in duration from 4 weeks to 18 months. 12,13In all studies, the RCTs had two-arm comparisons: (1) direct comparison of TMH vs same treatment delivered in-person, (2) TMH + In-person vs In-person alone (TMH as add on to usual care), (3) TMH intervention versus in-person standard care control, and (4) TMH vs another telehealth control (such as telephone-delivered calls recalling neutral events).][23][24][25] Three compared one telemental health treatment to another telehealth control, two of which were telephone-based and one video-telephone hybrid (17.6%). 13,26,27 terventions included communication between a provider and a patient via electronic means such as telephone, videoconference, or other digital media platforms.All 17 papers used digital communication either through telephone (58.9%) or webcam/videoconferencing (41.2%).The control for the 3 studies that compared 2 TMH interventions included telephone calls recalling neutral events, adherence reminder telephone calls, or telephone-based disease management modules. 13,26,27 scriptions of the interventions, controls, outcomes, and results are displayed in Table 2. Schulze described usual care as occasional in-person physician visits to evaluate illness compared to TMH as add-on to usual care. 18Chong used a webcam that consisted of monthly TMH visits provided by a psychiatrist using an online virtual meeting program. 15Both Lam and Schulze included components consisting of adherence-reminder telephone calls from trained nursing staff as part of their TMH intervention delivered via phone but had different comparison groups. 26,18Between the video-based and telephone-based subgroups, no outcome differences were seen (Tables 1 and 2). 26,18

Mood Outcomes
All 17 papers measured at least one clinical outcome (clinical depression, treatment response, medication adherence, patient acceptability, etc.).The majority of the papers (n = 12) had a primary outcome of change in mood symptoms among the following groups: TMH compared to in-person care alone, and the same treatment delivered via TMH and in-person.In the same intervention delivered via telehealth vs in-person comparison group, Chong found that while depression scores decreased more rapidly among treatment delivered via a video webcam vs in-person treatment group, there was no statistically significant difference in the depression score between the two groups. 15Luxton reported relatively strong and similar reductions in depression symptoms, hopelessness, and PTSD symptoms across both traditional office and videoconferencing groups comparing the same intervention. 16Egede found no significant differences between in-person treatment CBT compared with tCBT trajectories over time on the self-reported Beck Depression Inventory (BDI) and Geriatric Depression Scales (GDS). 11,12wo papers focused on telephone-administered cognitive behavioral therapy (tCBT) compared to in-person CBT control. 22,23Fann et al. found significant improvement on the patient-reported symptom checklist and greater satisfaction with depression care compared to the in-person group p < 0.001; however, there were no differences in clinician-rated Hamilton Depression Rating Scale (HAM-D) scores between the groups. 22Mohr did not find any significant difference in depression outcomes as measured by the clinician-rated HAM-D between patients receiving in-person treatment versus patients receiving tCBT. 23hree papers observed TMH treatment added on to usual care versus in-person usual care.Dobkin reported significant self-reported improvements in mood with tCBT compared to treatment as usual (TAU) which was defined by psychiatric consultations, medication management, supportive psychotherapy, and all aspects of routine care. 19Dennis examined clinical depression outcomes in post-partum patients between TMH interpersonal psychotherapy (IPT) plus in-person treatment versus in-person treatment alone. 20In this article, Dennis found that patients treated with both IPT and standard care were 4.5 times less likely to be clinically depressed than individuals in the standard local postpartum care group. 20hree papers examined mood outcomes in TMH vs telehealth control groups.Celano found improved positive affect, as measured by the Positive and Negative Affect Schedule (PANAS), as well as improved optimism and significant reductions in hopelessness, as measured by a five-point Likert scale, in the telephone-delivered positive psychology group compared to patients receiving telephone calls recalling neutral events. 13Lam et al. did not find a significant difference in depression change scores based on the Montgomery-Åsberg Depression Rating Scale (MADRS) after 12 weeks between patients who received escitalopram + tCBT vs those who received escitalopram + control telephone-based medication reminders. 26Hilty found clinical improvement for depression in both groups that received either telephone-based intensive disease management modules (IDMM) and televideo-based psychiatric consultation versus telephone-based disease management (DMM) alone with a significant trend favoring the IDMM group. 27

Medication Adherence
In three papers, medication adherence was a reported outcome.D'Souza reported increased treatment adherence, which resulted in fewer readmissions and relapses, when comparing inpatients who received team-based videoconference discharge planning and six telemedicine-based psychoeducational program sessions, compared to inpatients who received in-person discharge summaries and no psycho-educational program. 21In another study, Schulze found that patients who received regular telephone calls as stand-alone therapy from specially trained nurses were significantly more likely to be adherent to their medications at 6 months, according to the Medication Adherence Report Scale (MARS), compared to patients who only had intermittent in-person visits with a physician with no TMH intervention. 18inally, Kalapatapu reported that in-person CBT care and tCBT did not significantly differ in the number of CBT sessions attended, treatment engagement, treatment completion, or discontinuation of treatment. 17

Patient Satisfaction and Study Attrition
Patient satisfaction was a reported outcome in several included papers.Hulsbosch used the Geestelijke Gezondheidszorg (GGZ) Thermometer, a personalized patient satisfaction questionnaire, and found that videoconferencing compared to control in-person usual care had a positive effect on patient satisfaction. 14However, no significant difference was found between the two groups on quality of life, loneliness, daily functioning, or the fulfillment of needs of care. 14Similarly, Mohr reported that patients were significantly more satisfied with a 20-week program for depression using tCBT compared to treatment as usual. 23In addition, Lam stated that tCBT was well accepted with 79% of participants rating themselves as satisfied or highly satisfied with the therapy. 26In contrast, based on the Charleston Psychiatric Outpatient Satisfaction Scale (CPOSS), Egede et al. (2016)  found no significant difference in patient satisfaction or treatment credibility between TMH MDD medication treatment vs in-person MDD medication treatment. 12ata attrition or retention was noted in seven papers which provided a proxy for acceptability for positive clinical outcomes in different comparison groups. 11,12,16,19,20,26,27 In te TMH vs same treatment in-person group, Egede reported good patient retention with a range between 65 and 85% and excellent session attendance. 11Luxton reported that a total of 42 out of 82 participants completed all eight sessions of the same treatment as in-person care, and 40 completed all eight sessions using TMH, with a total attrition rate of 32.3%, and indicating no significant difference in attrition between the two groups. 16In the TMH vs telehealth control group, Hilty reported that retention was superior in the intervention group and that older participants were more likely to complete the study. 27In contrast, Lam found that in-person therapy had significantly higher attrition compared to the tCBT group and concluded that TMH is an acceptable method for CBT when compared to a telehealth control. 26

Study Quality Assessment
The MQRS results are found in Table 1.The scores ranged from 7 to 13 with higher scores reflecting greater the methodological quality.The average score was 10.29 ± 1.66.All 17 papers were defined as moderate study quality.Strengths in study quality included every study being an RCT and inclusion of pre-intervention baseline analysis.Limitations of the quality assessment included minimal multi-site locations (n = 3) and limited objective verification in the papers.

Discussion
TMH is a critical tool in the delivery of mental health and has demonstrated its ability to increase access to care. 3 TMH quickly expanded since the onset of the COVID-19 pandemic given travel restrictions and a greater need for mental health services by a limited pool of mental health clinicians. 28The transition to TMH happened out of necessity and did not necessarily incorporate the evidence base stemming from RCTs prior to the onset of the pandemic.This selective narrative review evaluated the efficacy of TMH for the treatment of individuals with serious mood disorders prior to the COVID-19 pandemic.

Mood Outcomes
With respect to clinical outcomes, when comparing TMH interventions for mood disorders to in-person care of the same intervention, this review found that there was minimal to no difference in the magnitude of improvement of symptoms.Similar to a 2010 systematic review by García-Lizana and Ingrid Muñoz-Mayorga which concluded that videoconference-based treatment in depression yields similar results as face-to-face therapy, 29 the results suggest that TMH was not inferior to in-person treatment modalities.When comparing TMH + in-person vs in-person alone for clinical depression in post-partum patients, the add-on group showed larger improvements in clinical depression compared to the control group, indicating that TMH when used as an add-on has the potential to amplify mood outcomes. 20In a parallel study conducted by Guaiana et al., a reduction of depressive symptoms was observed in both TMH and control groups in individuals with MDD. 30 Guaiana also showed that although TMH leads to symptom improvement in TMH in patients with mood disorders similar to in-person care, factors of relationship building, such as empathy and alliance between patient and psychiatrist over video, need further investigation. 30

Medication Adherence
Among the papers in the current review that examined medication adherence as an outcome, adherence improved with TMH and there were fewer readmissions and relapses.This may have important implications among patients in remote and rural areas where access to professional care is an issue. 21Additionally, telemedicine interventions for adherence allow the provider to address nonadherence outside of clinic and between visits.A 2020 systematic review by Basit found similar results.Namely, that TMH interventions may improve medication adherence in patients with depression, bipolar disorder, and schizophrenia. 31As TMH becomes increasingly more prevalent in the post-COVID-19 era, TMH interventions can be used to enhance in-person treatment and aid in medication adherence across various psychiatric disorders.However, further research is needed to better understand the mechanisms of change and the specific content of effective TMH interventions. 31

Patient Satisfaction and Study Attrition
As for patient satisfaction, while not consistent, in two studies, satisfaction was greater in TMH groups than same treatment in-person groups. 14,15A 2020 systematic review found that patient satisfaction is equivalent or significantly higher in TMH than face-to-face intervention in patients with MDD. 30 Benefits of TMH that improve patient satisfaction compared to in-person treatment include less travel time, minimizing time away from work, and improved scheduling convenience. 26Importantly, there is a need to determine which patient populations and particular patients are more likely to attend and follow through with TMH than with in-person care.In this way, there is the potential to engage more patients in the type of treatment that is most acceptable and suitable for them.
In several of the included studies, the feasibility of TMH use prior to the COVID-19 pandemic was measured through completed appointments and exercises, as well as service delivery perception. 12,13,15 MH has been shown to reduce travel costs and increase attendance, particularly for patients living in areas where psychiatric services are not locally available. 23,27One prospective study revealed that most patients would be willing to pay for such a service at home. 4 Potential barriers include user acceptance, older age, technological issues, and resistance among providers, all of which may inhibit the use of TMH. 15

Limitations and Strengths
While this review adds to the body of knowledge of TMH in mood disorders prior to COVID-19, there are several limitations that may impact generalizability.Less than 50% of the papers selected were carried out at multiple sites, all had generally small sample sizes, and there were a limited number of papers (n = 17).Furthermore, only 23.5% (n = 4) of the papers focused on individuals with BD, indicating that the conclusions may not be generalizable to this patient population and that further study of TMH for the treatment of BD is needed. 13,14,18,21 Frthermore, the samples of participants are from predominantly Caucasian, wealthy, Western nations, and may not be generalizable to countries outside of those sampled in this paper.As most of these papers were conducted in highly industrialized countries, this may introduce bias as the population is likely to have better access to TMH compared to other countries.Finally, many of these studies utilized basic technology (e.g., telephone, early versions of webcams) which may not compare to post-COVID video platforms.While the manuscript provides an overview of telehealth's potential in treating mood disorders, it falls short in concluding what works best for whom.There are several strengths of the narrative approach, however, that may in part offset methodological weaknesses.The inclusion of only RCTs helped to ensure a minimum of study rigor and better approximation of TMH outcome comparisons, while the global distribution of studies helped make conclusions more generalizable to the broader population of people with MDD and preliminary signal with BD.

Future Areas of Research
The narrative review findings also suggest areas for future research.There were few studies that investigated comparisons of TMH versus other telehealth interventions or TMH plus in-person versus in-person interventions alone.These areas can be further explored to better understand the utility of TMH across various domains.Conducting well-designed RCTs comparing the use of higher technology TMH interventions in patients with serious mood disorders post-COVID-19 could significantly add to the scientific knowledge base.Other future studies might include a greater focus on patients with BD, with greater awareness of barriers to treatment adherence, TMH for patients with mood disorders in rural areas, and needed refinements in TMH delivery such as the determination of videoconferencing best practices and other TMH therapies.

Implications for Behavioral Health
Use of TMH prior to the onset of the COVID-19 pandemic for treatment of serious mood disorders demonstrates the benefits of access to care and follow-up, with few apparent differences in clinical outcomes between TMH and in-person care.With the shift towards distance technology, TMH is a viable means for treating patients with MDD and possibly BD.Specific challenges for treating these patients may include barriers to technological access and how to augment TMH with needed in-person interventions such as medication injection or physical/neurological examination.These preliminary findings highlight the need for future work to investigate best use and practices for carrying out TMH for patients with serious mood disorders on a broader scale and in real-world settings.

Table 1
Study characteristics-demographics, setting, and duration of randomized controlled trial testing telemental health interventions in patients with serious mood disorders